| 标 题 | 刊 物 | 发表时间 | 研究内容 | 影响因子 |
Opioid-induced fragile-like regulatory T cells contribute to withdrawal | Cell | 1月19日 | 阿片类药物成瘾与外周免疫相关性及其机制研究 | 64 |
| Physical - and Chemical-Dually ROS-Responsive Nano-in-Gel Platforms with Sequential Release of OX40 Agonist and PD-1 Inhibitor for Augmented Combination Immunotherapy | Nano Lett | 2月13日 | 探索OX40激动剂和PD-1阻断剂序贯疗法的肿瘤浸润免疫细胞亚群 | 10.5 |
| Hydroxyphenylpyruvate dioxygenase is a metabolic immune checkpoint for UTX-deficient colorectal cancer | Gastroenterology | 2月20日 | 质谱流式研究UTX在重塑结肠直肠癌免疫微环境中的功能作用 | 28.7 |
| Disruption of SLFN11 Deficiency–Induced CCL2 Signaling and Macrophage M2 Polarization Potentiates Anti–PD-1 Therapy Efficacy in Hepatocellular Carcinoma | Gastroenterology | 2月27日 | 揭示SLFN11影响HCC肿瘤微环境的关键作用机制 | 28.7 |
| Runx3-overexpression cooperates with ex vivo AKT inhibition to generate receptor-engineered T cells with better persistence, tumor-residency, and antitumor ability | J Immunother Cancer | 2月27日 | 研究AKT抑制、Runx3过表达及其组合对小鼠CAR-T细胞表型的影响 | 10.4 |
| Single-cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-ring Cell Carcinoma | Gastroenterology | 3月14日 | 质谱流式技术研究胃癌免疫微环境 | 28.7 |
| Multidimensional Analysis of Lung Lymph Nodes in a Mouse Model of Allergic Lung Inflammation following PM2.5 and Indeno[1,2,3- cd]pyrene Exposure | Environ Health Perspect | 3月28日 | 研究PM2.5和茚并 (1,2,3-cd) 芘暴露后小鼠肺部淋巴结免疫状态改变 | 10.1 |
| Single-cell analysis highlights a population of Th17-polarized CD4+ naïve T cells showing IL6/JAK3/STAT3 activation in pediatric severe aplastic anemia. | J Autoimmun | 3月29日 | 获得性再生贫血患者的的免疫特征分析 | 12.6 |
| Effects of 3-HAA on HCC by Regulating the Heterogeneous Macrophages-A scRNA-Seq Analysis | Adv Sci (Weinh) | 4月4日 | 研究3-羟基-2-氨基苯甲酸治疗后肝癌免疫微环境 | 17 |
| Neutralizing IL-8 potentiates immune checkpoint blockade efficacy for glioma. | Cancer Cell | 4月10日 | 质谱流式技术研究恶性神经胶质瘤ICB治疗疗效 | 49.7 |
| Integration of Protein Nanocage with CpG Motifs: A Virus-Mimicked Core-Shell Nanostructure to Ignite Antitumor Immunity | Small | 6月7日 | 质谱流式分析类似于乙肝病毒结构的CpG@HB诱导的免疫反应特征，揭示其抗肿瘤机制 | 12.8 |
| Breaking Spatiotemporal Barriers of Immunogenic Chemotherapy via an Endoplasmic Reticulum Membrane-Assisted Liposomal Drug Delivery | ACS Nano | 6月13日 | 利用质谱流式和其他单细胞分析方法分析首次接触钙网蛋白(CRT)在诱导免疫原性中的关键重要性 | 16.4 |
| 2,5-dimethylcelecoxib alleviated NK and T-cell exhaustion in hepatocellular carcinoma via the gastrointestinal microbiota-AMPK-mTOR axis | J Immunother Cancer | 6月14日 | 质谱流式解析DMC(塞莱昔布衍生物)、塞来昔布和MK-886(一种已知的mPGES-1抑制剂)治疗的HCC小鼠的肿瘤微环境 | 10.4 |
| Single-cell analysis reveals the multiple patterns of immune escape in the nasopharyngeal carcinoma microenvironment | Clin Transl Med | 6月22日 | 组织成像质谱流式结合scRNA/snRNA-seq技术分析在单细胞分辨率下鼻咽癌肿瘤的转录组学 | 10.4 |
| Single-cell analysis reveals HBV-specific PD-1+CD8+ TRM cells in tumor borders are associated with HBV-related hepatic damage and fibrosis in HCC patients | J Exp Clin Cancer Res | 6月23日 | CyTOF分析免疫检查点阻断疗法(ICB)治疗乙肝病毒(HBV)感染的肝细胞癌(HBB)的免疫微环境 | 11.1 |
| Intratumoral PPT1-positive macrophages determine immunosuppressive contexture and immunotherapy response in hepatocellular carcinoma | J Immunother Cancer | 6月29日 | 通过Cytof和RNA测序技术发现肝细胞癌中的关键巨噬细胞亚群 | 10.4 |
| A gain-of-function variation in PLCG1 causes a new immune dysregulation disease | J Allergy Clin Immunol. | 7月6日 | PLCG1的功能获得变异导致新的免疫失调疾病 | 13.1 |
| Peripheral nerves directly mediate the transneuronal translocation of silver nanomaterials from the gut to central nervous system | Sci Adv | 7月7日 | 通过质谱流式研究周围神经直接介导银纳米材料从肠道到中枢神经系统的跨神经元易位 | 13.4 |
| A high-throughput mass cytometry barcoding platform recapitulating the immune features for HCC detection | Nano Today | 7月27日 | 开发了自动微滴打印平台，实现高通量质谱条形码策略 | 16.8 |
| Targeting MS4A4A on tumour-associated macrophages restores CD8+ T-cell-mediated antitumour immunity | Gut | 7月28日 | 质谱流式技术评估MS4A4A阻断剂对肿瘤免疫微环境的影响 | 23.9 |
| CRIP1 fosters MDSC trafficking and resets tumour microenvironment via facilitating NF-κB/p65 nuclear translocation in pancreatic ductal adenocarcinoma | Gut | 8月4日 | 利用质谱流式、组织成像质谱流式及其他方法研究CRIP1对胰腺癌微环境的影响 | 23.9 |
| Longitudinal high-dimensional analysis identifies immune features associating with response to anti-PD-1 immunotherapy | Nat Commun | 8月22日 | 对接受抗PD1治疗的非小细胞肺癌（NSCLC）患者的外周血样本进行了纵向免疫监测 | 16.2 |
| Single-cell mapping reveals several immune subsets associated with liver metastasis of pancreatic ductal adenocarcinoma | Med | 8月25日 | 利用质谱流式技术寻找胰腺导管腺的肿瘤微环境中与转移相关的免疫变化 | 17 |
| Spatial proteomics of immune microenvironment in nonalcoholic steatohepatitis-associated hepatocellular carcinoma | Hepatology | 9月21日 | 组织成像质谱流式研究非酒精性脂肪肝炎相关肝细胞癌免疫微环境 | 13 |
| Systemic immune profiling of Omicron-infected subjects inoculated with different doses of inactivated virus vaccine | Cell | 9月27日 | 质谱流式技术揭示新冠病毒疫苗接种对感染后免疫反应的影响 | 64 |
| Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma | J Hepatol | 10月12日 | 利用Cytof等多种技术研究肿瘤血管内皮细胞在 HCC 中的具体功能和机制 | 24.6 |
| SULT2B1-CS-DOCK2 axis regulates effector T-cell exhaustion in HCC microenvironment | Hepatology | 10月21日 | 质谱流式分析肝细胞癌 CD8 + T 细胞浸润的作用机制 | 13 |
| Identification and Characterization of CD8+ CD27+ CXCR3- T Cell Dysregulation and Progression-Associated Biomarkers in Systemic Lupus Erythematosus | Adv Sci (Weinh) | 10月24日 | 质谱流式研究系统性红斑狼疮的致病机制，发现潜在生物标志物 | 17 |
| The potential of swine pseudorabies virus attenuated vaccine for oncolytic therapy against malignant tumors | J Exp Clin Cancer Res | 10月27日 | 采用质谱流式(CyTOF)研究猪伪狂犬病病毒（PRV-LAV） 治疗对肿瘤免疫微环境的调节作用 | 11.1 |
| Oncogenic PIK3CA recruits myeloid-derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5-lipoxygenase-dependent arachidonic acid pathway | Clin Transl Med | 11月15日 | 采用 CyTOF 技术研究腔内乳腺癌致癌PIK3CA突变的肿瘤免疫微环境 | 10.4 |
| Single-cell RNA-sequencing atlas reveals an FABP1-dependent immunosuppressive environment in hepatocellular carcinoma | J Immunother Cancer | 11月24日 | 质谱流式分析FABP1-KO和WT小鼠的肿瘤微环境，发现FABP1缺失导致免疫激活 | 10.4 |
| High-dimensional single-cell proteomics analysis of esophageal squamous cell carcinoma reveals dynamic alterations of the tumor immune microenvironment after neoadjuvant therapy | J Immunother Cancer | 11月28日 | 质谱流式技术研究食管癌的新辅助治疗后肿瘤免疫微环境的动态变化 | 10.4 |
| Aldehyde dehydrogenase 2-mediated aldehyde metabolism promotes tumor immune evasion by regulating the NOD/VISTA axis | J Immunother Cancer | 12月8日 | 质谱流式研究抑制ALDH2重塑肿瘤免疫景观 | 10.4 |
| A self-assembled graphene oxide adjuvant induces both enhanced humoral and cellular immune responses in influenza vaccine | J Control Release | 12月11日 | 质谱流式研究新型佐剂在流感疫苗中诱导增强的细胞免疫反应 | 10.2 |
